Enhanced Transdermal Delivery of Diclofenac Sodium via Conventional Liposomes, Ethosomes, and Transfersomes
Joint Authors
Ghanbarzadeh, Saeed
Arami, Sanam
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to improve the transdermal permeation of Diclofenac sodium, a poorly water-soluble drug, employing conventional liposomes, ethosomes, and transfersomes.
The prepared formulations had been characterized for the loaded drug amount and vesicle size.
The prepared vesicular systems were incorporated into 1% Carbopol 914 gel, and a survey of in vitro drug release and drug retention into rat skin has been done on them using a modified Franz diffusion cell.
The cumulative amount of drug permeated after 24 h, flux, and permeability coefficient were assessed.
Stability studies were performed for three months.
The size of vesicles ranged from 145 to 202 nm, and the encapsulation efficiency of the Diclofenac sodium was obtained between 42.61% and 51.72%.
The transfersomes and ethosomes provided a significantly higher amount of cumulative permeation, steady state flux, permeability coefficient, and residual drug into skin compared to the conventional liposomes, conventional gel, or hydroethanolic solution.
The in vitro release data of all vesicular systems were well fit into Higuchi model (RSD > 0.99).
Stability tests indicated that the vesicular formulations were stable over three months.
Results revealed that both ethosome and transfersome formulations can act as drug reservoir in skin and extend the pharmacologic effects of Diclofenac sodium.
American Psychological Association (APA)
Ghanbarzadeh, Saeed& Arami, Sanam. 2013. Enhanced Transdermal Delivery of Diclofenac Sodium via Conventional Liposomes, Ethosomes, and Transfersomes. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004727
Modern Language Association (MLA)
Ghanbarzadeh, Saeed& Arami, Sanam. Enhanced Transdermal Delivery of Diclofenac Sodium via Conventional Liposomes, Ethosomes, and Transfersomes. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1004727
American Medical Association (AMA)
Ghanbarzadeh, Saeed& Arami, Sanam. Enhanced Transdermal Delivery of Diclofenac Sodium via Conventional Liposomes, Ethosomes, and Transfersomes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004727