Comparison of Prostate-Specific Promoters and the Use of PSP-Driven Virotherapy for Prostate Cancer
Joint Authors
Lu, Yi
Zhang, Yu
Chang, Guimin
Zhang, Jun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer deaths in men today.
Although virus-based gene therapy is a promising strategy to combat advanced prostate cancer, its current effectiveness is limited partially due to inefficient cellular transduction in vivo.
To overcome this obstacle, conditional oncolytic viruses (such as conditional replication adenovirus (CRAD)) are developed to specifically target prostate without (or with minimal) systemic toxicity due to viral self-replication.
In this study, we have analyzed and compared three prostate-specific promoters (PSA, probasin, and MMTV LTR) for their specificity and activity both in vitro and in vivo.
Both mice model with xenograft prostate tumor model and canine model were used.
The best PSP was selected to construct a prostate-specific oncolytic adenovirus (CRAD) by controlling the adenoviral E1 region.
The efficacy and specificity of CRAD on prostate cancer cells were examined in cell culture and animal models.
American Psychological Association (APA)
Lu, Yi& Zhang, Yu& Chang, Guimin& Zhang, Jun. 2013. Comparison of Prostate-Specific Promoters and the Use of PSP-Driven Virotherapy for Prostate Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004746
Modern Language Association (MLA)
Lu, Yi…[et al.]. Comparison of Prostate-Specific Promoters and the Use of PSP-Driven Virotherapy for Prostate Cancer. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1004746
American Medical Association (AMA)
Lu, Yi& Zhang, Yu& Chang, Guimin& Zhang, Jun. Comparison of Prostate-Specific Promoters and the Use of PSP-Driven Virotherapy for Prostate Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004746