The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening
Joint Authors
Casagrande, Rúbia
Verri, Waldiceu A.
Calixto-Campos, Cassia
Zarpelon, Ana C.
Corrêa, Mab
Cardoso, Renato D. R.
Pinho-Ribeiro, Felipe A.
Cecchini, Rubens
Moreira, Estefania G.
Crespigio, Jefferson
Bernardy, Catia C. F.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The Ehrlich tumor is a mammary adenocarcinoma of mice that can be developed in solid and ascitic forms depending on its administration in tissues or cavities, respectively.
The present study investigates whether the subcutaneous plantar administration of the Ehrlich tumor cells induces pain-like behavior and initial pharmacological susceptibility characteristics.
The Ehrlich tumor cells (1 × 104–107 cells) induced dose-dependent mechanical hyperalgesia (electronic version of the von Frey filaments), paw edema/tumor growth (caliper), and flinches compared with the saline group between days 2 and 12.
There was no difference between doses of cells regarding thermal hyperalgesia in the hot-plate test.
Indomethacin (a cyclooxygenase inhibitor) and amitriptyline hydrochloride (a tricyclic antidepressant) treatments did not affect flinches or thermal and mechanical hyperalgesia.
On the other hand, morphine (an opioid) inhibited the flinch behavior and the thermal and mechanical hyperalgesia.
These effects of morphine on pain-like behavior were prevented by naloxone (an opioid receptor antagonist) treatment.
None of the treatments affected paw edema/tumor growth.
The results showed that, in addition to tumor growth, administration of the Ehrlich tumor cells may represent a novel model for the study of cancer pain, specially the pain that is susceptible to treatment with opioids, but not to cyclooxygenase inhibitor or to tricyclic antidepressant.
American Psychological Association (APA)
Calixto-Campos, Cassia& Zarpelon, Ana C.& Corrêa, Mab& Cardoso, Renato D. R.& Pinho-Ribeiro, Felipe A.& Cecchini, Rubens…[et al.]. 2013. The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004747
Modern Language Association (MLA)
Calixto-Campos, Cassia…[et al.]. The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004747
American Medical Association (AMA)
Calixto-Campos, Cassia& Zarpelon, Ana C.& Corrêa, Mab& Cardoso, Renato D. R.& Pinho-Ribeiro, Felipe A.& Cecchini, Rubens…[et al.]. The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004747