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Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells
Joint Authors
Li, Chunyi
Pearson, Allan
McMahon, Chris
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-07
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
We have made comparisons between hair follicles (HFs) and antler units (AUs)—two seemingly unrelated mammalian organs.
HFs are tiny and concealed within skin, whereas AUs are gigantic and grown externally for visual display.
However, these two organs share some striking similarities.
Both consist of permanent and cyclic/temporary components and undergo stem-cell-based organogenesis and cyclic regeneration.
Stem cells of both organs reside in the permanent part and the growth centres are located in the temporary part of each respective organ.
Organogenesis and regeneration of both organs depend on epithelial-mesenchymal interactions.
Establishment of these interactions requires stem cells and reactive/niche cells (dermal papilla cells for HFs and epidermal cells for AUs) to be juxtaposed, which is achieved through destruction of the cyclic part to bring the reactive cells into close proximity to the respective stem cell niche.
Developments of HFs and AUs are regulated by similar endocrine (particularly testosterone) and paracrine (particularly IGF1) factors.
Interestingly, these two organs come to interplay during antlerogenesis.
In conclusion, we believe that investigators from the fields of both HF and AU biology could greatly benefit from a comprehensive comparison between these two organs.
American Psychological Association (APA)
Li, Chunyi& Pearson, Allan& McMahon, Chris. 2013. Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-1004798
Modern Language Association (MLA)
Li, Chunyi…[et al.]. Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells. BioMed Research International No. 2013 (2013), pp.1-21.
https://search.emarefa.net/detail/BIM-1004798
American Medical Association (AMA)
Li, Chunyi& Pearson, Allan& McMahon, Chris. Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-1004798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004798