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Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders
Joint Authors
Jongkamonwiwat, Nopporn
Noisa, Parinya
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neurological disorders are characterized by the chronic and progressive loss of neuronal structures and functions.
There is a variability of the onsets and causes of clinical manifestations.
Cell therapy has brought a new concept to overcome brain diseases, but the advancement of this therapy is limited by the demands of specialized neurons.
Human pluripotent stem cells (hPSCs) have been promised as a renewable resource for generating human neurons for both laboratory and clinical purposes.
By the modulations of appropriate signalling pathways, desired neuron subtypes can be obtained, and induced pluripotent stem cells (iPSCs) provide genetically matched neurons for treating patients.
These hPSC-derived neurons can also be used for disease modeling and drug screening.
Since the most urgent problem today in transplantation is the lack of suitable donor organs and tissues, the derivation of neural progenitor cells from hPSCs has opened a new avenue for regenerative medicine.
In this review, we summarize the recent reports that show how to generate neural derivatives from hPSCs, and discuss the current evidence of using these cells in animal studies.
We also highlight the possibilities and concerns of translating these hPSC-derived neurons for biomedical and clinical uses in order to fight against neurological disorders.
American Psychological Association (APA)
Jongkamonwiwat, Nopporn& Noisa, Parinya. 2013. Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004815
Modern Language Association (MLA)
Jongkamonwiwat, Nopporn& Noisa, Parinya. Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1004815
American Medical Association (AMA)
Jongkamonwiwat, Nopporn& Noisa, Parinya. Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004815