Patent Ductus Arteriosus in Preterm Infants: Do We Have the Right Answers?
Joint Authors
Abdel-Hady, Hesham
Nasef, Nehad
Shabaan, Abd Elazeez
Nour, Islam
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Patent ductus arteriosus (PDA) is a common clinical condition in preterm infants.
Preterm newborns with PDA are at greater risk for several morbidities, including higher rates of bronchopulmonary dysplasia (BPD), decreased perfusion of vital organs, and mortality.
Therefore, cyclooxygenase (COX) inhibitors and surgical interventions for ligation of PDA are widely used.
However, these interventions were reported to be associated with side effects.
In the absence of clear restricted rules for application of these interventions, different strategies are adopted by neonatologists.
Three different approaches have been investigated including prophylactic treatment shortly after birth irrespective of the state of PDA, presymptomatic treatment using echocardiography at variable postnatal ages to select infants for treatment prior to the duct becoming clinically significant, and symptomatic treatment once PDA becomes clinically apparent or hemodynamically significant.
Future appropriately designed randomized controlled trials (RCTs) to refine selection of patients for medical and surgical treatments should be conducted.
Waiting for new evidence, it seems wise to employ available clinical and echocardiographic parameters of a hemodynamically significant (HS) PDA to select patients who are candidates for medical treatment.
Surgical ligation of PDA could be used as a back-up tool for those patients who failed medical treatment and continued to have hemodynamic compromise.
American Psychological Association (APA)
Abdel-Hady, Hesham& Nasef, Nehad& Shabaan, Abd Elazeez& Nour, Islam. 2013. Patent Ductus Arteriosus in Preterm Infants: Do We Have the Right Answers?. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004828
Modern Language Association (MLA)
Abdel-Hady, Hesham…[et al.]. Patent Ductus Arteriosus in Preterm Infants: Do We Have the Right Answers?. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1004828
American Medical Association (AMA)
Abdel-Hady, Hesham& Nasef, Nehad& Shabaan, Abd Elazeez& Nour, Islam. Patent Ductus Arteriosus in Preterm Infants: Do We Have the Right Answers?. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004828