Antagonistic Activity of Lactobacillus Isolates against Salmonella typhi In Vitro
Joint Authors
Ashour, Mohammed Seif El-Din
Mabrouk Aboulwafa, Mohammad
Abdel-Daim, Amira
Hassouna, Nadia
Hafez, Mohamed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Enteric fever is a global health problem, and rapidly developing resistance to various drugs makes the situation more alarming.
The potential use of Lactobacillus to control typhoid fever represents a promising approach, as it may exert protective actions through various mechanisms.
Methods.
In this study, the probiotic potential and antagonistic activities of 32 Lactobacillus isolates against Salmonella typhi were evaluated.
The antimicrobial activity of cell free supernatants of Lactobacillus isolates, interference of Lactobacillus isolates with the Salmonella adherence and invasion, cytoprotective effect of Lactobacillus isolates, and possibility of concurrent use of tested Lactobacillus isolates and antibiotics were evaluated by testing their susceptibilities to antimicrobial agents, and their oxygen tolerance was also examined.
Results.
The results revealed that twelve Lactobacillus isolates could protect against Salmonella typhi infection through interference with both its growth and its virulence properties, such as adherence, invasion, and cytotoxicity.
These Lactobacillus isolates exhibited MIC values for ciprofloxacin higher than those of Salmonella typhi and oxygen tolerance and were identified as Lactobacillus plantarum.
Conclusion.
The tested Lactobacillus plantarum isolates can be introduced as potential novel candidates that have to be subjected for in vivo and application studies for treatment and control of typhoid fever.
American Psychological Association (APA)
Abdel-Daim, Amira& Hassouna, Nadia& Hafez, Mohamed& Ashour, Mohammed Seif El-Din& Mabrouk Aboulwafa, Mohammad. 2013. Antagonistic Activity of Lactobacillus Isolates against Salmonella typhi In Vitro. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004841
Modern Language Association (MLA)
Abdel-Daim, Amira…[et al.]. Antagonistic Activity of Lactobacillus Isolates against Salmonella typhi In Vitro. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004841
American Medical Association (AMA)
Abdel-Daim, Amira& Hassouna, Nadia& Hafez, Mohamed& Ashour, Mohammed Seif El-Din& Mabrouk Aboulwafa, Mohammad. Antagonistic Activity of Lactobacillus Isolates against Salmonella typhi In Vitro. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004841