Genetic Analysis of Clinical VZV Isolates Collected in China Reveals a More Homologous Profile
Joint Authors
Wang, Mingli
Chen, Jason
Jiang, Longfeng
Gan, Lin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Forty-four varicella-zoster virus (VZV) isolates from China were genotyped by using a scattered single nucleotide polymorphism (SNP) method, including open reading frames (ORFs) 1, 22, 31, 37, 60, 62, 67, and 68.
Based on the analysis of the polymorphic markers in the 8 ORFs, all of the 44 isolates can be placed in genotype J defined by the SNP profiles in ORF22 or clade B defined by the SNP profiles in ORFs 31, 37, 60, 62, 67, and 68.
The three consecutive nucleotide (CGG) in-frame insertions in ORF 1 were found in 8 (18.2%) isolates, which has not been described in VZV strains from any other part of the world.
A novel synonymous A>G substitution in ORF60 was revealed in 4 (9.1%) of the isolates.
In addition, a previously described three consecutive nucleotide (ATC) insertion in ORF 60 was found in all the Chinese isolates but not in the US isolate MLS.
The results showed all the 44 strains that belong to genotype J/clade B with significantly high homogeneity, and phylogenetic analysis suggested that the 44 Chinese isolates consist of 4 clusters, but interstrain variations also exist.
Overall, VZV isolates obtained in China showed significantly higher genetic homogeneity than isolates reported from other countries.
American Psychological Association (APA)
Jiang, Longfeng& Gan, Lin& Chen, Jason& Wang, Mingli. 2013. Genetic Analysis of Clinical VZV Isolates Collected in China Reveals a More Homologous Profile. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004845
Modern Language Association (MLA)
Jiang, Longfeng…[et al.]. Genetic Analysis of Clinical VZV Isolates Collected in China Reveals a More Homologous Profile. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004845
American Medical Association (AMA)
Jiang, Longfeng& Gan, Lin& Chen, Jason& Wang, Mingli. Genetic Analysis of Clinical VZV Isolates Collected in China Reveals a More Homologous Profile. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004845