Molecular Characterization of BK and JC Viruses Circulating among Potential Kidney Donors in Kuwait
Joint Authors
Chehadeh, Wassim
Kurien, Susan Silpi
Nampoory, Mangalathillam Raman
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
BK and JC polyomaviruses can be associated with nephropathy following renal transplantation.
The aim of this study was to determine the prevalence, load, and genotypes of BK and JC viruses circulated in potential kidney donors in Kuwait.
The detection of polyomavirus DNA was carried out in serum and urine samples of 165 potential kidney donors.
Seventy (42%) individuals were tested positive for polyomavirus DNA, of whom 20 (12%) had detectable polyomavirus DNA in their serum samples, 40 (24%) in their urine samples, and 10 (6%) in both serum and urine samples.
In the group of polyomavirus-positive patients, JC DNA could be detected in 78% of urine samples and 11% of serum samples, whereas BK DNA could be detected in 7% of urine samples and 3% of serum samples.
The median polyomaviral load was low.
The detected BK sequences in Kuwaiti adults formed new clusters sharing common ancestor with subgroups Ib1 and IVc, which are prevalent in Asia and Europe.
Additionally, around half of the detected JCV sequences in Kuwaiti adults formed new clusters within the African subtype 3.
Our results suggest high rate of polyomavirus shedding among healthy adults in Kuwait that can jeopardize their suitability for kidney donation.
American Psychological Association (APA)
Chehadeh, Wassim& Kurien, Susan Silpi& Nampoory, Mangalathillam Raman. 2013. Molecular Characterization of BK and JC Viruses Circulating among Potential Kidney Donors in Kuwait. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004850
Modern Language Association (MLA)
Chehadeh, Wassim…[et al.]. Molecular Characterization of BK and JC Viruses Circulating among Potential Kidney Donors in Kuwait. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1004850
American Medical Association (AMA)
Chehadeh, Wassim& Kurien, Susan Silpi& Nampoory, Mangalathillam Raman. Molecular Characterization of BK and JC Viruses Circulating among Potential Kidney Donors in Kuwait. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004850