Long-Term Impact of Immunosuppressants at Therapeutic Doses on Male Reproductive System in Unilateral Nephrectomized Rats: A Comparative Study
Joint Authors
Chen, Yehui
Zhang, Zhi
Lin, Yun
Lin, Huaxin
Li, Miaoyuan
Nie, Pin
Chen, Lizhong
Qiu, Jiang
Lu, Yanmeng
Chen, Linqiang
Xu, Banglao
Lin, Wuzhou
Zhang, Jing
Du, Hong
Liang, Jianjian
Zhang, Zhiwei
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cyclosporine, tacrolimus, and sirolimus are commonly used in renal transplant recipients to prevent rejection.
However, information for comparative effects of these agents on the male productive system is extremely limited and controversial.
In a physiologically and clinically relevant rat model of unilateral nephrectomy, we demonstrated that long-term oral administration of both cyclosporine and sirolimus at doses equivalent to the therapeutic levels used for postrenal transplant patients significantly affects testicular development and the hypothalamic-pituitary-gonadal axis accompanied by profound histological changes of testicular structures on both light and electron microscopic examinations.
Spermatogenesis was also severely impaired as indicated by low total sperm counts along with reduction of sperm motility and increase in sperm abnormality after treatment with these agents, which may lead to male infertility.
On the other hand, treatment with therapeutic dose of tacrolimus only induced mild reduction of sperm count without histological evidence of testicular injury.
The current study clearly demonstrates that commonly used immunosuppressants have various impacts on male reproductive system even at therapeutic levels.
Our data provide useful information for the assessment of male infertility in renal transplant recipients who wish to father children.
Clinical trials to address these issues should be urged.
American Psychological Association (APA)
Chen, Yehui& Zhang, Zhi& Lin, Yun& Lin, Huaxin& Li, Miaoyuan& Nie, Pin…[et al.]. 2013. Long-Term Impact of Immunosuppressants at Therapeutic Doses on Male Reproductive System in Unilateral Nephrectomized Rats: A Comparative Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004875
Modern Language Association (MLA)
Chen, Yehui…[et al.]. Long-Term Impact of Immunosuppressants at Therapeutic Doses on Male Reproductive System in Unilateral Nephrectomized Rats: A Comparative Study. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004875
American Medical Association (AMA)
Chen, Yehui& Zhang, Zhi& Lin, Yun& Lin, Huaxin& Li, Miaoyuan& Nie, Pin…[et al.]. Long-Term Impact of Immunosuppressants at Therapeutic Doses on Male Reproductive System in Unilateral Nephrectomized Rats: A Comparative Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004875