Overexpression of RKIP Inhibits Cell Invasion in Glioma Cell Lines through Upregulation of miR-98
Joint Authors
Chen, Zigui
Cheng, Quan
Ma, Zhiming
Xi, Haipeng
Peng, Renjun
Jiang, Bing
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Raf-1 kinase inhibitor protein (RKIP) is a tumor and metastasis suppressor in cancer cells.
MicroRNAs (miRNAs) have been suggested to play a vital role in tumor initiation and progression by negatively regulating oncogenes and tumor suppressors.
Quite recently, studies have identified some miRNAs operating to promote or suppress tumor invasion or metastasis via regulating metastasis-related genes, providing potential therapeutic targets on antimetastasis strategy.
In this study, we found that the expression of RKIP and miR-98 in glioma tissues were significantly lower than that in normal brain tissues.
Overexpression of RKIP upregulated miR-98 expression and inhibited glioma cell invasion and miR-98 target gene HMGA2 but had no effect in glioma cell proliferation.
Moreover, forced expression of miR-98 accelerated the inhibition of glioma cell invasion and the expression of HMGA2 also had no effect in glioma cell proliferation.
Our findings newly described RKIP/miR-98 to HMGA2 link and provided a potential mechanism for glioma cell invasion.
RKIP and miR-98 may illustrate the potential therapeutic utility of signaling pathway signatures.
American Psychological Association (APA)
Chen, Zigui& Cheng, Quan& Ma, Zhiming& Xi, Haipeng& Peng, Renjun& Jiang, Bing. 2013. Overexpression of RKIP Inhibits Cell Invasion in Glioma Cell Lines through Upregulation of miR-98. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004890
Modern Language Association (MLA)
Chen, Zigui…[et al.]. Overexpression of RKIP Inhibits Cell Invasion in Glioma Cell Lines through Upregulation of miR-98. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1004890
American Medical Association (AMA)
Chen, Zigui& Cheng, Quan& Ma, Zhiming& Xi, Haipeng& Peng, Renjun& Jiang, Bing. Overexpression of RKIP Inhibits Cell Invasion in Glioma Cell Lines through Upregulation of miR-98. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004890