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Distal Airway Impairment in Obese Normoreactive Women
Joint Authors
Marin, Grégory
Gamez, Anne Sophie
Molinari, Nicolas
Kacimi, Djamila
Vachier, Isabelle
Paganin, Fabrice
Chanez, Pascal
Bourdin, Arnaud
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Asthma-like symptoms are frequent in overweight and obesity, but the mechanism is unclear when airway hyperresponsiveness (AHR) is lacking.
In this study, we focused on obese women with a clinical suspicion of asthma but negative methacholine challenge and tested distal airway hyperreactivity, explored by Forced Vital Capacity dose-response slope (FVC DRS).
Objective.
To question AHR at the distal airway level in obese women.
Methods.
A total of 293 symptomatic obese and nonobese women free of treatment were investigated.
Methacholine challenge tests were undertaken, and patients were divided according to their results to the test.
In hyperreactive and nonhyperreactive patients and in our total population, correlations, regression analyses, and analyses of covariance were performed to compare distal airway hyperreactivity in three groups of body mass index (BMI).
Results.
After adjusting for age and baseline respiratory values, the relationship between FVC and FEV1 (forced expiratory volume in one second) DRS was influenced by BMI, with a lower slope in obese than overweight and normal patients in our total population (P=0.008) and in our nonhyperreactive one (P=0.028).
Conclusion.
Distal airway hyperresponsiveness was observed in symptomatic wheezing obese women negative to methacholine challenge.
American Psychological Association (APA)
Marin, Grégory& Gamez, Anne Sophie& Molinari, Nicolas& Kacimi, Djamila& Vachier, Isabelle& Paganin, Fabrice…[et al.]. 2013. Distal Airway Impairment in Obese Normoreactive Women. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004925
Modern Language Association (MLA)
Marin, Grégory…[et al.]. Distal Airway Impairment in Obese Normoreactive Women. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004925
American Medical Association (AMA)
Marin, Grégory& Gamez, Anne Sophie& Molinari, Nicolas& Kacimi, Djamila& Vachier, Isabelle& Paganin, Fabrice…[et al.]. Distal Airway Impairment in Obese Normoreactive Women. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004925