Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes
Joint Authors
Whitmont, K.
Fulcher, G.
Reid, I.
Xue, M.
McKelvey, K.
Xie, Y.
Aboud, M.
Ward, C.
Smith, M. M.
Cooper, A.
March, L.
Jackson, C. J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Activated protein C (APC) promotes angiogenesis and reepithelialisation and accelerates healing of diabetic ulcers.
The aim of this study was to determine the relationship between the incidence of lower leg ulcers and plasma levels of APC's precursor, protein C (PC), in diabetic patients.
Patients with diabetes who had a lower leg ulcer(s) for >6 months (n=36) were compared with age-, type of diabetes-, and sex-matched subjects with diabetes but without an ulcer (n=36, controls).
Total PC was assessed using a routine PC colorimetric assay.
There was a significantly (P<0.001) lower level of plasma PC in patients with ulcers (103.3 ± 22.7, mean ± SD) compared with control (127.1±34.0) subjects, when corrected for age and matched for gender and type of diabetes.
Ulcer type (neuropathic, ischaemic, or mixed) was not a significant covariate for plasma PC levels (P=0.35).
There was no correlation between PC levels and gender, type of diabetes, HbA1c, or C-reactive protein in either group.
In summary, decreased circulating PC levels are associated with, and may predispose to, lower leg ulceration in patients with diabetes.
American Psychological Association (APA)
Whitmont, K.& Fulcher, G.& Reid, I.& Xue, M.& McKelvey, K.& Xie, Y.…[et al.]. 2013. Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1004946
Modern Language Association (MLA)
Whitmont, K.…[et al.]. Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1004946
American Medical Association (AMA)
Whitmont, K.& Fulcher, G.& Reid, I.& Xue, M.& McKelvey, K.& Xie, Y.…[et al.]. Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1004946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004946