The Sonodynamic Effect of Curcumin on THP-1 Cell-Derived Macrophages
Joint Authors
Wang, Fengping
Gao, Qianping
Guo, Shuyuan
Cheng, Jiali
Sun, Xin
Li, Qiannan
Wang, Tengyu
Zhang, Zhiguo
Cao, Wenwu
Tian, Ye
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Curcumin is extracted from the rhizomes of the traditional Chinese herb Curcuma longa and has been proposed to function as a photosensitizer.
The potential use of curcumin as a sonosensitizer for sonodynamic therapy (SDT) requires further exploration.
This study investigated the sonodynamic effect of curcumin on macrophages, the pivotal inflammatory cells in atherosclerotic plaque.
THP-1-derived macrophages were incubated with curcumin at a concentration of 40.7 μmol/L for 2 h and then exposed to pulse ultrasound irradiation (2 W/cm2 with 0.86 MHz) for 5–15 min.
Six hours later, cell viability was decreased in cells that had been treated with ultrasound for 10 and 15 min.
After ultrasound irradiation for 15 min, the ratio of apoptotic and necrotic cells in SDT group was higher than that in ultrasound group, and the ratio of apoptotic cells was higher than that of necrotic cells.
Both loss of mitochondrial membrane potential and morphological changes of cytoskeleton were apparent 2 h after treatment with curcumin SDT.
These findings support that curcumin had sonodynamic effect on THP-1-derived macrophages and that curcumin SDT could be a promising treatment for atherosclerosis.
American Psychological Association (APA)
Guo, Shuyuan& Cheng, Jiali& Sun, Xin& Li, Qiannan& Wang, Tengyu& Zhang, Zhiguo…[et al.]. 2012. The Sonodynamic Effect of Curcumin on THP-1 Cell-Derived Macrophages. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004997
Modern Language Association (MLA)
Guo, Shuyuan…[et al.]. The Sonodynamic Effect of Curcumin on THP-1 Cell-Derived Macrophages. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004997
American Medical Association (AMA)
Guo, Shuyuan& Cheng, Jiali& Sun, Xin& Li, Qiannan& Wang, Tengyu& Zhang, Zhiguo…[et al.]. The Sonodynamic Effect of Curcumin on THP-1 Cell-Derived Macrophages. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004997