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Increasing Hematopoietic Stem Cell Yield to Develop Mice with Human Immune Systems
Joint Authors
Biancotti, Juan-Carlos
Town, Terrence
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hematopoietic stem cells (HSCs) are unique in their capacity to give rise to all mature cells of the immune system.
For years, HSC transplantation has been used for treatment of genetic and neoplastic diseases of the hematopoietic and immune systems.
The sourcing of HSCs from human umbilical cord blood has salient advantages over isolation from mobilized peripheral blood.
However, poor sample yield has prompted development of methodologies to expand HSCs ex vivo.
Cytokines, trophic factors, and small molecules have been variously used to promote survival and proliferation of HSCs in culture, whilst strategies to lower the concentration of inhibitors in the culture media have recently been applied to promote HSC expansion.
In this paper, we outline strategies to expand HSCs in vitro, and to improve engraftment and reconstitution of human immune systems in immunocompromised mice.
To the extent that these “humanized” mice are representative of the endogenous human immune system, they will be invaluable tools for both basic science and translational medicine.
American Psychological Association (APA)
Biancotti, Juan-Carlos& Town, Terrence. 2013. Increasing Hematopoietic Stem Cell Yield to Develop Mice with Human Immune Systems. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005005
Modern Language Association (MLA)
Biancotti, Juan-Carlos& Town, Terrence. Increasing Hematopoietic Stem Cell Yield to Develop Mice with Human Immune Systems. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005005
American Medical Association (AMA)
Biancotti, Juan-Carlos& Town, Terrence. Increasing Hematopoietic Stem Cell Yield to Develop Mice with Human Immune Systems. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005005