Structure and Antimicrobial Properties of Monensin A and Its Derivatives: Summary of the Achievements

Abstract EN

In this paper structural and microbiological studies on the ionophorous antibiotic monensin A and its derivatives have been collected.

Monensin A is an ionophore which selectively complexes and transports sodium cation across lipid membranes, and therefore it shows a variety of biological properties.

This antibiotic is commonly used as coccidiostat and nonhormonal growth promoter.

The paper focuses on both the latest and earlier achievements concerning monensin A antimicrobial activity.

The activities of monensin derivatives, including modifications of hydroxyl groups and carboxyl group, are also presented.