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Advanced Systems Biology Methods in Drug Discovery and Translational Biomedicine
Joint Authors
Zou, Jun
Zheng, Ming-Wu
Li, Gen
Su, Zhi-Guang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Systems biology is in an exponential development stage in recent years and has been widely utilized in biomedicine to better understand the molecular basis of human disease and the mechanism of drug action.
Here, we discuss the fundamental concept of systems biology and its two computational methods that have been commonly used, that is, network analysis and dynamical modeling.
The applications of systems biology in elucidating human disease are highlighted, consisting of human disease networks, treatment response prediction, investigation of disease mechanisms, and disease-associated gene prediction.
In addition, important advances in drug discovery, to which systems biology makes significant contributions, are discussed, including drug-target networks, prediction of drug-target interactions, investigation of drug adverse effects, drug repositioning, and drug combination prediction.
The systems biology methods and applications covered in this review provide a framework for addressing disease mechanism and approaching drug discovery, which will facilitate the translation of research findings into clinical benefits such as novel biomarkers and promising therapies.
American Psychological Association (APA)
Zou, Jun& Zheng, Ming-Wu& Li, Gen& Su, Zhi-Guang. 2013. Advanced Systems Biology Methods in Drug Discovery and Translational Biomedicine. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005013
Modern Language Association (MLA)
Zou, Jun…[et al.]. Advanced Systems Biology Methods in Drug Discovery and Translational Biomedicine. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005013
American Medical Association (AMA)
Zou, Jun& Zheng, Ming-Wu& Li, Gen& Su, Zhi-Guang. Advanced Systems Biology Methods in Drug Discovery and Translational Biomedicine. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005013