Hereditary Breast Cancer: The Era of New Susceptibility Genes
Joint Authors
Apostolou, Paraskevi
Fostira, Florentia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Breast cancer is the most common malignancy among females.
5%–10% of breast cancer cases are hereditary and are caused by pathogenic mutations in the considered reference BRCA1 and BRCA2 genes.
As sequencing technologies evolve, more susceptible genes have been discovered and BRCA1 and BRCA2 predisposition seems to be only a part of the story.
These new findings include rare germline mutations in other high penetrant genes, the most important of which include TP53 mutations in Li-Fraumeni syndrome, STK11 mutations in Peutz-Jeghers syndrome, and PTEN mutations in Cowden syndrome.
Furthermore, more frequent, but less penetrant, mutations have been identified in families with breast cancer clustering, in moderate or low penetrant genes, such as CHEK2, ATM, PALB2, and BRIP1.
This paper will summarize all current data on new findings in breast cancer susceptibility genes.
American Psychological Association (APA)
Apostolou, Paraskevi& Fostira, Florentia. 2013. Hereditary Breast Cancer: The Era of New Susceptibility Genes. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005022
Modern Language Association (MLA)
Apostolou, Paraskevi& Fostira, Florentia. Hereditary Breast Cancer: The Era of New Susceptibility Genes. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005022
American Medical Association (AMA)
Apostolou, Paraskevi& Fostira, Florentia. Hereditary Breast Cancer: The Era of New Susceptibility Genes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005022