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Cancer Morbidity in Rheumatoid Arthritis: Role of Estrogen Metabolites
Joint Authors
Khan, Wahid Ali
Khan, Mohd Wajid Ali
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Estrogen metabolites have been implicated in rheumatoid arthritis (RA) and cancer, although the mechanism remains unestablished.
Some estrogen metabolites, which are used for the assessment of cancer risk, play an important role in RA.
The pathways by which malignancies associated with RA remain elusive.
Possible mechanism involves enzymatic or nonenzymatic oxidation of estrogen into catecholestrogen metabolites through semiquinone and quinone redox cycle to produce free radicals that can cause DNA modifications.
Modifications of DNA alter its immunogenicity and trigger various immune responses leading to elevated levels of cancer and RA antibodies.
However, the role of different estrogen metabolites as a mediator of immune response cannot be ruled out in various immune-related diseases.
American Psychological Association (APA)
Khan, Wahid Ali& Khan, Mohd Wajid Ali. 2013. Cancer Morbidity in Rheumatoid Arthritis: Role of Estrogen Metabolites. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005025
Modern Language Association (MLA)
Khan, Wahid Ali& Khan, Mohd Wajid Ali. Cancer Morbidity in Rheumatoid Arthritis: Role of Estrogen Metabolites. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005025
American Medical Association (AMA)
Khan, Wahid Ali& Khan, Mohd Wajid Ali. Cancer Morbidity in Rheumatoid Arthritis: Role of Estrogen Metabolites. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005025