Potential Use of Atlantic Cod Trypsin in Biomedicine
Joint Authors
Gudmundsdóttir, Ágústa
Hilmarsson, Hilmar
Stefansson, Bjarki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases.
Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin.
In this paper, cod trypsin is shown to be 3–12 times more effective in degrading large native proteins than its mesophilic analogue, bovine trypsin.
This is in agreement with previous findings where cod trypsin was found to be the most active among twelve different proteases in cleaving various cytokines and pathological proteins.
Furthermore, our results show that cod trypsin has high efficacy against herpes simplex virus type 1 (HSV-1) and the respiratory syncytial virus (RSV) in vitro.
The results on the antipathogenic properties of cod trypsin are important because rhinovirus, RSV, and influenza are the most predominant pathogenic viruses in upper respiratory tract infections.
Results from a clinical study presented in this paper show that a specific formulation containing cod trypsin was preferred for wound healing over other methods used in the study.
Apparently, the high digestive ability of the cold-adapted cod trypsin towards large native proteins plays a role in its efficacy against pathogens and its positive effects on wounds.
American Psychological Association (APA)
Gudmundsdóttir, Ágústa& Hilmarsson, Hilmar& Stefansson, Bjarki. 2013. Potential Use of Atlantic Cod Trypsin in Biomedicine. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005027
Modern Language Association (MLA)
Gudmundsdóttir, Ágústa…[et al.]. Potential Use of Atlantic Cod Trypsin in Biomedicine. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005027
American Medical Association (AMA)
Gudmundsdóttir, Ágústa& Hilmarsson, Hilmar& Stefansson, Bjarki. Potential Use of Atlantic Cod Trypsin in Biomedicine. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005027