Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals
Joint Authors
Zhang, Tao
Lv, Chunfang
Li, Liling
Chen, Sihan
Liu, Shenglin
Wang, Changyi
Su, Bing
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) is a major public health problem in China.
Diagnostic markers are urgently needed to identify individuals at risk of developing T2DM and encourage them to adapt to a healthier life style.
Circulating miRNAs present important sources of noninvasive biomarkers of various diseases.
Recently, a novel plasma microRNA signature was identified in T2DM.
Here, we evaluated the T2DM-related miRNA signature in plasma of three study groups: normal (fasting glucose (FG), 4.8–5.2 mmol/L), T2DM-susceptible (FG, 6.1–6.9 mmol/L), and T2DM individuals (FG, ≥7.0 mmol/L) and tested the feasibility of using circulating miRNAs to identify individuals at risk of developing T2DM.
Among the 5 miRNAs included in the signature, miR-29b and miR-28-3p are not detectable.
miR-15a and miR-223 have comparable expression levels among three groups.
Notably, miR-126 is the only miRNA that showed significantly reduced expression in susceptible individuals and T2DM patients compared to normal individuals, suggesting that miR-126 in circulation may serve as a potential biomarker for early identification of susceptible individuals to T2DM.
American Psychological Association (APA)
Zhang, Tao& Lv, Chunfang& Li, Liling& Chen, Sihan& Liu, Shenglin& Wang, Changyi…[et al.]. 2013. Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005070
Modern Language Association (MLA)
Zhang, Tao…[et al.]. Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005070
American Medical Association (AMA)
Zhang, Tao& Lv, Chunfang& Li, Liling& Chen, Sihan& Liu, Shenglin& Wang, Changyi…[et al.]. Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005070