Multiple Biomarker Panels for Early Detection of Breast Cancer in Peripheral Blood
Joint Authors
Zhang, Fan
Deng, Youping
Drabier, Renee
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Detecting breast cancer at early stages can be challenging.
Traditional mammography and tissue microarray that have been studied for early breast cancer detection and prediction have many drawbacks.
Therefore, there is a need for more reliable diagnostic tools for early detection of breast cancer due to a number of factors and challenges.
In the paper, we presented a five-marker panel approach based on SVM for early detection of breast cancer in peripheral blood and show how to use SVM to model the classification and prediction problem of early detection of breast cancer in peripheral blood.
We found that the five-marker panel can improve the prediction performance (area under curve) in the testing data set from 0.5826 to 0.7879.
Further pathway analysis showed that the top four five-marker panels are associated with signaling, steroid hormones, metabolism, immune system, and hemostasis, which are consistent with previous findings.
Our prediction model can serve as a general model for multibiomarker panel discovery in early detection of other cancers.
American Psychological Association (APA)
Zhang, Fan& Deng, Youping& Drabier, Renee. 2013. Multiple Biomarker Panels for Early Detection of Breast Cancer in Peripheral Blood. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005091
Modern Language Association (MLA)
Zhang, Fan…[et al.]. Multiple Biomarker Panels for Early Detection of Breast Cancer in Peripheral Blood. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005091
American Medical Association (AMA)
Zhang, Fan& Deng, Youping& Drabier, Renee. Multiple Biomarker Panels for Early Detection of Breast Cancer in Peripheral Blood. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005091