Integrative Analysis of Methylome and Transcriptome Reveals the Importance of Unmethylated CpGs in Non-CpG Island Gene Activation
Joint Authors
Marx, Amichai
Kahan, Tamar
Simon, Itamar
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Promoter methylation is associated with gene repression; however, little is known about its mechanism.
It was proposed that the repression of methylated genes is achieved through the recruitment of methyl binding proteins (MBPs) that participate in closing the chromatin.
An alternative mechanism suggests that methylation interferes with the binding of either site specific activators or more general activators that bind to the CpG dinucleotide.
However, the relative contribution of these two mechanisms to gene repression is not known.
Results.
Bioinformatics analyses of genome-wide transcriptome and methylome data support the latter hypothesis by demonstrating a strong association between transcription and the number of unmethylated CpGs at the promoter of genes lacking CpG islands.
Conclusions.
Our results suggest that methylation represses gene expression mainly by preventing the binding of CpG binding activators.
American Psychological Association (APA)
Marx, Amichai& Kahan, Tamar& Simon, Itamar. 2013. Integrative Analysis of Methylome and Transcriptome Reveals the Importance of Unmethylated CpGs in Non-CpG Island Gene Activation. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005108
Modern Language Association (MLA)
Marx, Amichai…[et al.]. Integrative Analysis of Methylome and Transcriptome Reveals the Importance of Unmethylated CpGs in Non-CpG Island Gene Activation. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005108
American Medical Association (AMA)
Marx, Amichai& Kahan, Tamar& Simon, Itamar. Integrative Analysis of Methylome and Transcriptome Reveals the Importance of Unmethylated CpGs in Non-CpG Island Gene Activation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005108