Cell Transplantation for Spinal Cord Injury: A Systematic Review
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-32, 32 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-15
Country of Publication
Egypt
No. of Pages
32
Main Subjects
Abstract EN
Cell transplantation, as a therapeutic intervention for spinal cord injury (SCI), has been extensively studied by researchers in recent years.
A number of different kinds of stem cells, neural progenitors, and glial cells have been tested in basic research, and most have been excluded from clinical studies because of a variety of reasons, including safety and efficacy.
The signaling pathways, protein interactions, cellular behavior, and the differentiated fates of experimental cells have been studied in vitro in detail.
Furthermore, the survival, proliferation, differentiation, and effects on promoting functional recovery of transplanted cells have also been examined in different animal SCI models.
However, despite significant progress, a “bench to bedside” gap still exists.
In this paper, we comprehensively cover publications in the field from the last years.
The most commonly utilized cell lineages were covered in this paper and specific areas covered include survival of grafted cells, axonal regeneration and remyelination, sensory and motor functional recovery, and electrophysiological improvements.
Finally we also review the literature on the in vivo tracking techniques for transplanted cells.
American Psychological Association (APA)
Li, Jun& Lepski, Guilherme. 2013. Cell Transplantation for Spinal Cord Injury: A Systematic Review. BioMed Research International،Vol. 2013, no. 2013, pp.1-32.
https://search.emarefa.net/detail/BIM-1005111
Modern Language Association (MLA)
Li, Jun& Lepski, Guilherme. Cell Transplantation for Spinal Cord Injury: A Systematic Review. BioMed Research International No. 2013 (2013), pp.1-32.
https://search.emarefa.net/detail/BIM-1005111
American Medical Association (AMA)
Li, Jun& Lepski, Guilherme. Cell Transplantation for Spinal Cord Injury: A Systematic Review. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-32.
https://search.emarefa.net/detail/BIM-1005111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005111