Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients
Joint Authors
Beberashvili, Ilia
Sinuani, Inna
Azar, Ada
Kadoshi, Hadas
Shapiro, Gregory
Feldman, Leonid
Sandbank, Judith
Averbukh, Zhan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Obestatin, a proposed anorexigenic gut hormone, has been shown to have a number of beneficial cardiotropic effects in experimental studies.
We hypothesized that obestatin alteration in hemodialysis patients may link to clinical outcomes.
This cross-sectional study with prospective followup for almost 4 years was performed on 94 prevalent hemodialysis patients.
Obestatin, leptin, proinflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin-6, and various nutritional markers were measured.
Patients with low obestatin levels, defined as a level less than median, had a worse all-cause mortality and cardiovascular mortality.
The crude all-cause (HR 2.23, 95% CI 1.17 to 4.24) and cardiovascular mortality hazard ratios (HR 4.03, 95% CI 1.27 to 12.76) in these patients continued to be significant after adjustment for various confounders for all-cause mortality.
Across the four obestatin-TNF-α categories, the group with low obestatin and high TNF-α (above median level) exhibited a worse outcome in both all-cause mortality and cardiovascular mortality.
Clinical characteristics of patients in low obestatin high TNF-α group did not differ from other obestatin-TNF-α categorized groups.
In summary, low serum obestatin concentration is an independent predictor of mortality in prevalent hemodialysis patients.
Novel interactions were observed between obestatin and TNF-α, which were associated with mortality risk, especially those due to cardiovascular causes.
American Psychological Association (APA)
Beberashvili, Ilia& Sinuani, Inna& Azar, Ada& Kadoshi, Hadas& Shapiro, Gregory& Feldman, Leonid…[et al.]. 2013. Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005141
Modern Language Association (MLA)
Beberashvili, Ilia…[et al.]. Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005141
American Medical Association (AMA)
Beberashvili, Ilia& Sinuani, Inna& Azar, Ada& Kadoshi, Hadas& Shapiro, Gregory& Feldman, Leonid…[et al.]. Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005141