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Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier
Joint Authors
Bengalli, Rossella
Camatini, Marina
Gualtieri, Maurizio
Mantecca, Paride
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly.
During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented.
As a consequence, the understanding of the possible effects of NPs and PM on human respiratory system and particularly on the air-blood barrier (ABB) has become of primary interest.
The crosstalk between lung epithelial cells and underlying endothelial cells is indeed essential in determining the effects of inhaled particles.
Here we report the effects of metal oxides NPs (CuO and TiO2) and of PM on an in vitro model of the ABB constituted by the type II epithelial cell line (NCI-H441) and the endothelial one (HPMEC-ST1.6R).
The results demonstrate that apical exposure of alveolar cells induces significant modulation of proinflammatory proteins also in endothelial cells.
American Psychological Association (APA)
Bengalli, Rossella& Mantecca, Paride& Camatini, Marina& Gualtieri, Maurizio. 2012. Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005147
Modern Language Association (MLA)
Bengalli, Rossella…[et al.]. Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005147
American Medical Association (AMA)
Bengalli, Rossella& Mantecca, Paride& Camatini, Marina& Gualtieri, Maurizio. Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005147