On the Structural Context and Identification of Enzyme Catalytic Residues
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Enzymes play important roles in most of the biological processes.
Although only a small fraction of residues are directly involved in catalytic reactions, these catalytic residues are the most crucial parts in enzymes.
The study of the fundamental and unique features of catalytic residues benefits the understanding of enzyme functions and catalytic mechanisms.
In this work, we analyze the structural context of catalytic residues based on theoretical and experimental structure flexibility.
The results show that catalytic residues have distinct structural features and context.
Their neighboring residues, whether sequence or structure neighbors within specific range, are usually structurally more rigid than those of noncatalytic residues.
The structural context feature is combined with support vector machine to identify catalytic residues from enzyme structure.
The prediction results are better or comparable to those of recent structure-based prediction methods.
American Psychological Association (APA)
Chien, Yu-Tung& Huang, Shao-Wei. 2013. On the Structural Context and Identification of Enzyme Catalytic Residues. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005153
Modern Language Association (MLA)
Chien, Yu-Tung& Huang, Shao-Wei. On the Structural Context and Identification of Enzyme Catalytic Residues. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005153
American Medical Association (AMA)
Chien, Yu-Tung& Huang, Shao-Wei. On the Structural Context and Identification of Enzyme Catalytic Residues. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005153