Genetic Epidemiology, Hematological and Clinical Features of Hemoglobinopathies in Iran
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
There is large variation in the molecular genetics and clinical features of hemoglobinopathies in Iran.
Studying structural variants of hemoglobin demonstrated that the β-chain variants of hemoglobin S and D-Punjab are more prevalent in the Fars (southwestern Iran) and Kermanshah (western Iran) provinces, respectively.
Also, α-chain variants of Hb Q-Iran and Hb Setif are prevalent in western Iran.
The molecular basis and clinical severity of thalassemias are extremely heterogenous among Iranians due to the presence of multiethnic groups in the country.
β-Thalassemia is more prevalent in northern and southern Iran.
Among 52 different β-thalassemia mutations that have been identified among Iranian populations, IVSII-1 G:A is the most frequent mutation in most parts of the country.
The presence of IVS I-5 G:C mutation with high frequency in southeastern Iran might reflect gene flow from neighboring countries.
A wide spectrum of α-thalassemia alleles has been detected among Iranians with −α3.7 kb as the most prevalent α-thalassemia mutation.
The prevention program of thalassemia birth in Iran has reduced the birth rate of homozygous β-thalassemia since the implementation of the program in 1997.
In this review genetic epidemiology, clinical and hematological aspects of hemoglobinopathies, and the prevention programs of β-thalassemia in Iran will be discussed.
American Psychological Association (APA)
Rahimi, Zohreh. 2013. Genetic Epidemiology, Hematological and Clinical Features of Hemoglobinopathies in Iran. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005154
Modern Language Association (MLA)
Rahimi, Zohreh. Genetic Epidemiology, Hematological and Clinical Features of Hemoglobinopathies in Iran. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005154
American Medical Association (AMA)
Rahimi, Zohreh. Genetic Epidemiology, Hematological and Clinical Features of Hemoglobinopathies in Iran. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005154