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Propionibacterium acnes: An Underestimated Pathogen in Implant-Associated Infections
Joint Authors
Portillo, María Eugenia
Corvec, Stéphane
Borens, Olivier
Trampuz, Andrej
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The role of Propionibacterium acnes in acne and in a wide range of inflammatory diseases is well established.
However, P.
acnes is also responsible for infections involving implants.
Prolonged aerobic and anaerobic agar cultures for 14 days and broth cultures increase the detection rate.
In this paper, we review the pathogenic role of P.
acnes in implant-associated infections such as prosthetic joints, cardiac devices, breast implants, intraocular lenses, neurosurgical devices, and spine implants.
The management of severe infections caused by P.
acnes involves a combination of antimicrobial and surgical treatment (often removal of the device).
Intravenous penicillin G and ceftriaxone are the first choice for serious infections, with vancomycin and daptomycin as alternatives, and amoxicillin, rifampicin, clindamycin, tetracycline, and levofloxacin for oral treatment.
Sonication of explanted prosthetic material improves the diagnosis of implant-associated infections.
Molecular methods may further increase the sensitivity of P.
acnes detection.
Coating of implants with antimicrobial substances could avoid or limit colonization of the surface and thereby reduce the risk of biofilm formation during severe infections.
Our understanding of the role of P.
acnes in human diseases will likely continue to increase as new associations and pathogenic mechanisms are discovered.
American Psychological Association (APA)
Portillo, María Eugenia& Corvec, Stéphane& Borens, Olivier& Trampuz, Andrej. 2013. Propionibacterium acnes: An Underestimated Pathogen in Implant-Associated Infections. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005157
Modern Language Association (MLA)
Portillo, María Eugenia…[et al.]. Propionibacterium acnes: An Underestimated Pathogen in Implant-Associated Infections. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005157
American Medical Association (AMA)
Portillo, María Eugenia& Corvec, Stéphane& Borens, Olivier& Trampuz, Andrej. Propionibacterium acnes: An Underestimated Pathogen in Implant-Associated Infections. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005157