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Cellular and Axonal Diversity in Molecular Layer Heterotopia of the Rat Cerebellar Vermis
Joint Authors
Van Dine, Sarah E.
Salem, Elsaid
George, Elizabeth
Siu, Nga Yan
Dotzler, Timothy
Ramos, Raddy L.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Molecular layer heterotopia of the cerebellar primary fissure are a characteristic of many rat strains and are hypothesized to result from defect of granule cells exiting the external granule cell layer during cerebellar development.
However, the cellular and axonal constituents of these malformations remain poorly understood.
In the present report, we use histochemistry and immunocytochemistry to identify neuronal, glial, and axonal classes in molecular layer heterotopia.
In particular, we identify parvalbumin-expressing molecular layer interneurons in heterotopia as well as three glial cell types including Bergmann glia, Olig2-expressing oligodendrocytes, and Iba1-expressing microglia.
In addition, we document the presence of myelinated, serotonergic, catecholaminergic, and cholinergic axons in heterotopia indicating possible spinal and brainstem afferent projections to heterotopic cells.
These findings are relevant toward understanding the mechanisms of normal and abnormal cerebellar development.
American Psychological Association (APA)
Van Dine, Sarah E.& Salem, Elsaid& George, Elizabeth& Siu, Nga Yan& Dotzler, Timothy& Ramos, Raddy L.. 2013. Cellular and Axonal Diversity in Molecular Layer Heterotopia of the Rat Cerebellar Vermis. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005162
Modern Language Association (MLA)
Van Dine, Sarah E.…[et al.]. Cellular and Axonal Diversity in Molecular Layer Heterotopia of the Rat Cerebellar Vermis. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1005162
American Medical Association (AMA)
Van Dine, Sarah E.& Salem, Elsaid& George, Elizabeth& Siu, Nga Yan& Dotzler, Timothy& Ramos, Raddy L.. Cellular and Axonal Diversity in Molecular Layer Heterotopia of the Rat Cerebellar Vermis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1005162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005162