Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide
Joint Authors
Ghosh, Amitava
Chakraborty, Prithviraj
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Frusemide loaded calcium alginate micropellets, an oral microparticulate delivery system, was statistically optimized exhibiting prolonged therapeutic action minimizing its adverse effects.
Methods.
Ionotropic Gelation technique was adopted employing 32 Factorial designs and keeping the entire process free from organic solvents.
Physicochemical and the release characteristics of the prepared formulations were studied, keeping variations only in sodium alginate (primary polymer) and Acrycoat E30D (copolymer) dispersion.
Result.
Sodium alginate was predominant over Acrycoat E30D in all batches.
Nonadditives or interaction was observed to be insignificant.
Multiple regressions produced second-order polynomial equation, and the predictive results obtained were validated with high degree of correlation.
The in vivo study applauded that optimized calcium alginate micropellets of frusemide can produce a much greater diuretic effect over an extended period of 24 hours.
Conclusion.
This study reveals that the potential of a single dose of the mathematically optimized micro pellets of frusemide formulation is sufficient in the management of peripheral edema and ascites in congestive heart failure and as well in the treatment of chronic hypertension, leading to better patient compliance, and can be produced with minimum experimentation and time, proving far more cost-effective formulation than the conventional methods of formulating dosage forms.
American Psychological Association (APA)
Ghosh, Amitava& Chakraborty, Prithviraj. 2013. Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1005194
Modern Language Association (MLA)
Ghosh, Amitava& Chakraborty, Prithviraj. Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1005194
American Medical Association (AMA)
Ghosh, Amitava& Chakraborty, Prithviraj. Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1005194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005194