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Possible Mechanisms of Fullerene C60 Antioxidant Action
Joint Authors
Chistyakov, V. A.
Smirnova, Yu. O.
Prazdnova, E. V.
Soldatov, A. V.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Novel mechanism of antioxidant activity of buckminsterfullerene C60 based on protons absorbing and mild uncoupling of mitochondrial respiration and phosphorylation was postulated.
In the present study we confirm this hypothesis using computer modeling based on Density Functional Theory.
Fullerene's geroprotective activity is sufficiently higher than those of the most powerful reactive oxygen species scavengers.
We propose here that C60 has an ability to acquire positive charge by absorbing inside several protons and this complex could penetrate into mitochondria.
Such a process allows for mild uncoupling of respiration and phosphorylation.
This, in turn, leads to the decrease in ROS production.
American Psychological Association (APA)
Chistyakov, V. A.& Smirnova, Yu. O.& Prazdnova, E. V.& Soldatov, A. V.. 2013. Possible Mechanisms of Fullerene C60 Antioxidant Action. BioMed Research International،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1005199
Modern Language Association (MLA)
Chistyakov, V. A.…[et al.]. Possible Mechanisms of Fullerene C60 Antioxidant Action. BioMed Research International No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1005199
American Medical Association (AMA)
Chistyakov, V. A.& Smirnova, Yu. O.& Prazdnova, E. V.& Soldatov, A. V.. Possible Mechanisms of Fullerene C60 Antioxidant Action. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1005199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005199