Analgesic and Anti-Inflammatory Activities of the Methanolic Stem Bark Extract of Nyctanthes arbor-tristis Linn.

Abstract EN

Stem bark of Nyctanthes arbor-tristis Linn.

was extracted in methanol to evaluate their analgesic and anti-inflammatory activities.

The analgesic activity was determined on Wistar albino rats by hot plate method, tail flick assay, and tail immersion method using Morphine sulphate as standard drug at a dose of 5 mg/kg of body weight and the results were expressed as mean increase in latency after drug administration ± SEM.

The anti-inflammatory activity was assessed by Carrageenan-induced rat paw oedema using diclofenac sodium as standard drug at a dose of 100 mg/kg of body weight and expressed in terms of mean increase in paw volume ± SEM.

Stem bark extract was given at a dose of 250 mg/kg and 500 mg/kg of body weight.

Both standard drugs and extract were administered orally to the animals.

Control received distilled water orally.

Results showed that Nyctanthes arbor-tristis Linn.

had potent analgesic and anti-inflammatory activities.