Treatment of Nonhealing Diabetic Lower Extremity Ulcers with Skin Graft and Autologous Platelet Gel: A Case Series
Joint Authors
Tzeng, Yuan-Sheng
Deng, Shou-Cheng
Wang, Chih-Hsing
Tsai, Jui-Che
Chen, Tim-Mo
Burnouf, Thierry
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lower extremity ulcers in diabetic patients are difficult to treat.
Recently, the use of human blood platelet-derived components in this indication has been raising interest.
In this study, we have evaluated the safety and efficacy of the combination of autologous platelet gel (PG) and skin graft for treating large size recalcitrant ulcers.
Eight consecutive diabetic patients aged 25 to 82 with nine nonhealing lower extremity ulcers (median size of 50 cm2; range 15–150 cm2) were treated.
Skin ulcer was debrided, and the wound was sprayed after 7 to 10 days with autologous platelet-rich plasma and thrombin.
Thin split-thickness skin graft with multiple slits was then applied on the wound bed and fixed with staples or cat-gut sutures.
There were no adverse reactions observed during the study.
Eight out of 9 skin grafts took well.
The interval between skin graft and complete wound healing ranged from 2 to 3 weeks in the 8 successful cases.
No ulcer recurrence was noted in those patients during the follow-up period of 2 to 19 months.
In this study, the combination of autologous platelet gel and skin grafting has proven beneficial to heal large-size recalcitrant ulcers.
American Psychological Association (APA)
Tzeng, Yuan-Sheng& Deng, Shou-Cheng& Wang, Chih-Hsing& Tsai, Jui-Che& Chen, Tim-Mo& Burnouf, Thierry. 2013. Treatment of Nonhealing Diabetic Lower Extremity Ulcers with Skin Graft and Autologous Platelet Gel: A Case Series. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005233
Modern Language Association (MLA)
Tzeng, Yuan-Sheng…[et al.]. Treatment of Nonhealing Diabetic Lower Extremity Ulcers with Skin Graft and Autologous Platelet Gel: A Case Series. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005233
American Medical Association (AMA)
Tzeng, Yuan-Sheng& Deng, Shou-Cheng& Wang, Chih-Hsing& Tsai, Jui-Che& Chen, Tim-Mo& Burnouf, Thierry. Treatment of Nonhealing Diabetic Lower Extremity Ulcers with Skin Graft and Autologous Platelet Gel: A Case Series. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005233