Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury
Joint Authors
Chen, Shan
Meng, Xian-Fang
Zhang, Chun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006).
Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012).
Reactive oxygen species (ROS) are cellular signals which are closely associated with the development and progression of glomerular sclerosis.
NADPH oxidase is a district enzymatic source of cellular ROS production and prominently expressed in podocytes (Zhang et al., 2010).
In the last decade, it has become evident that NADPH oxidase-derived ROS overproduction is a key trigger of podocyte injury, such as renin-angiotensin-aldosterone system activation (Whaley-Connell et al., 2006), epithelial-to-mesenchymal transition (Zhang et al., 2011), and inflammatory priming (Abais et al., 2013).
This review focuses on the mechanism of NADPH oxidase-mediated ROS in podocyte injury under different pathophysiological conditions.
In addition, we also reviewed the therapeutic perspectives of NADPH oxidase in kidney diseases related to podocyte injury.
American Psychological Association (APA)
Chen, Shan& Meng, Xian-Fang& Zhang, Chun. 2013. Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005238
Modern Language Association (MLA)
Chen, Shan…[et al.]. Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005238
American Medical Association (AMA)
Chen, Shan& Meng, Xian-Fang& Zhang, Chun. Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005238