Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression
Joint Authors
Pavao, Mauro S. G.
Gomes, Angélica M.
Stelling, Mariana P.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Breast cancer is defined as a cancer originating in tissues of the breast, frequently in ducts and lobules.
During the last 30 years, studies to understand the biology and to treat breast tumor improved patients’ survival rates.
These studies have focused on genetic components involved in tumor progression and on tumor microenvironment.
Heparan sulfate proteoglycans (HSPGs) are involved in cell signaling, adhesion, extracellular matrix assembly, and growth factors storage.
As a central molecule, HSPG regulates cell behavior and tumor progression.
HS accompanied by its glycosaminoglycan counterparts regulates tissue homeostasis and cancer development.
These molecules present opposite effects according to tumor type or cancer model.
Studies in this area may contribute to unveil glycosaminoglycan activities on cell dynamics during breast cancer exploring these polysaccharides as antitumor agents.
Heparanase is a potent tumor modulator due to its protumorigenic, proangiogenic, and prometastatic activities.
Several lines of evidence indicate that heparanase is upregulated in all human sarcomas and carcinomas.
Heparanase seems to be related to several aspects regulating the potential of breast cancer metastasis.
Due to its multiple roles, heparanase is seen as a target in cancer treatment.
We will describe recent findings on the function of HSPGs and heparanase in breast cancer behavior and progression.
American Psychological Association (APA)
Gomes, Angélica M.& Stelling, Mariana P.& Pavao, Mauro S. G.. 2013. Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005273
Modern Language Association (MLA)
Gomes, Angélica M.…[et al.]. Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005273
American Medical Association (AMA)
Gomes, Angélica M.& Stelling, Mariana P.& Pavao, Mauro S. G.. Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005273