Spleen Stiffness Correlates with the Presence of Ascites but Not Esophageal Varices in Chronic Hepatitis C Patients
Joint Authors
Mori, Kazuyo
Arai, Hirotaka
Abe, Takehiko
Takayama, Hisashi
Toyoda, Mitsuo
Ueno, Takashi
Sato, Ken
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Although spleen stiffness has recently been identified as potential surrogate marker for portal hypertension, the relationship between spleen stiffness and portal hypertension has not been fully elucidated.
We attempted to determine the relationship between the liver or spleen stiffness and the presence of ascites or esophageal varices by acoustic radiation force impulse (ARFI) imaging.
A total of 33 chronic hepatitis C (CHC) patients (median age 68; range 51–84) were enrolled.
We evaluated the relationship between the liver or spleen stiffness and indicators of portal hypertension as well as clinical and biochemical parameters.
Fourteen healthy volunteers were used for validating the accuracy of AFRI imaging.
The liver and spleen stiffness increased significantly with progression of liver disease.
A significant positive correlation was observed between the liver and spleen stiffness.
However, spleen stiffness, but not liver stiffness, was significantly associated with the presence of ascites (P<0.05), while there was no significant association between the spleen stiffness and spleen index/presence of esophageal varices in CHC patients.
The area under the receiver operating characteristic curve based on the spleen stiffness was 0.80.
In conclusion, spleen stiffness significantly correlates with the presence of ascites but not esophageal varices in CHC patients.
American Psychological Association (APA)
Mori, Kazuyo& Arai, Hirotaka& Abe, Takehiko& Takayama, Hisashi& Toyoda, Mitsuo& Ueno, Takashi…[et al.]. 2013. Spleen Stiffness Correlates with the Presence of Ascites but Not Esophageal Varices in Chronic Hepatitis C Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005288
Modern Language Association (MLA)
Mori, Kazuyo…[et al.]. Spleen Stiffness Correlates with the Presence of Ascites but Not Esophageal Varices in Chronic Hepatitis C Patients. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005288
American Medical Association (AMA)
Mori, Kazuyo& Arai, Hirotaka& Abe, Takehiko& Takayama, Hisashi& Toyoda, Mitsuo& Ueno, Takashi…[et al.]. Spleen Stiffness Correlates with the Presence of Ascites but Not Esophageal Varices in Chronic Hepatitis C Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005288