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Treatment with Anti-Interleukin 23 Antibody Ameliorates Disease in Lupus-Prone Mice
Joint Authors
Tsokos, George C.
Kyttaris, Vasileios C.
Kampagianni, Ourania
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Interleukin 23 receptor expressing IL-17 producing T cells have been shown to be important in the development of murine lupus.
The usefulness of IL-23 inhibition in ameliorating lupus nephritis is unknown.
We hypothesized that inhibition of IL-23 will ameliorate nephritis in lupus-prone mice.
To this end, we treated MRL/lpr lupus-prone mice for 6 weeks with a rat anti-IL-23p19 antibody, which resulted in delaying the onset of nephritis without affecting the production of anti-dsDNA antibodies.
The effect of the treatment was hampered by the production of murine anti-rat IgG antibodies.
The amelioration of murine lupus by IL-23 inhibition strengthens the rationale for targeting IL-23 in patients with systemic lupus erythematosus.
American Psychological Association (APA)
Kyttaris, Vasileios C.& Kampagianni, Ourania& Tsokos, George C.. 2013. Treatment with Anti-Interleukin 23 Antibody Ameliorates Disease in Lupus-Prone Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005295
Modern Language Association (MLA)
Kyttaris, Vasileios C.…[et al.]. Treatment with Anti-Interleukin 23 Antibody Ameliorates Disease in Lupus-Prone Mice. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1005295
American Medical Association (AMA)
Kyttaris, Vasileios C.& Kampagianni, Ourania& Tsokos, George C.. Treatment with Anti-Interleukin 23 Antibody Ameliorates Disease in Lupus-Prone Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005295