MUC1-Specific Cytotoxic T Lymphocytes in Cancer Therapy: Induction and Challenge
Joint Authors
Roulois, David
Grégoire, Marc
Fonteneau, Jean-François
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
MUC1 glycoprotein is often found overexpressed and hypoglycosylated in tumor cells from numerous cancer types.
Since its discovery MUC1 has been an attractive target for antitumor immunotherapy.
Indeed, in vitro and in vivo experiments have shown T-cell-specific responses against MUC1 in an HLA-restricted and HLA-unrestricted manner, although some animal models have highlighted the possible development of tolerogenic responses against this antigen.
These observations permit the development of new T-cell vaccine strategies capable of inducing an MUC1-specific cytotoxic T cell response in cancer patients.
Some of these strategies are now being tested in clinical trials against different types of cancer.
To date, encouraging clinical responses have been observed with some MUC1 vaccines in phase II/III clinical trials.
This paper compiles knowledge regarding MUC1 as a promising tumor antigen for antitumor therapeutic vaccines applicable to numerous cancers.
We also summarize the results of MUC1-vaccine-based clinical trials.
American Psychological Association (APA)
Roulois, David& Grégoire, Marc& Fonteneau, Jean-François. 2012. MUC1-Specific Cytotoxic T Lymphocytes in Cancer Therapy: Induction and Challenge. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005319
Modern Language Association (MLA)
Roulois, David…[et al.]. MUC1-Specific Cytotoxic T Lymphocytes in Cancer Therapy: Induction and Challenge. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005319
American Medical Association (AMA)
Roulois, David& Grégoire, Marc& Fonteneau, Jean-François. MUC1-Specific Cytotoxic T Lymphocytes in Cancer Therapy: Induction and Challenge. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005319