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Hyperpolarization-Activated Current, If, in Mathematical Models of Rabbit Sinoatrial Node Pacemaker Cells
Joint Authors
Verkerk, Arie O.
Wilders, Ronald
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-08
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
A typical feature of sinoatrial (SA) node pacemaker cells is the presence of an ionic current that activates upon hyperpolarization.
The role of this hyperpolarization-activated current, If, which is also known as the “funny current” or “pacemaker current,” in the spontaneous pacemaker activity of SA nodal cells remains a matter of intense debate.
Whereas some conclude that If plays a fundamental role in the generation of pacemaker activity and its rate control, others conclude that the role of If is limited to a modest contribution to rate control.
The ongoing debate is often accompanied with arguments from computer simulations, either to support one's personal view or to invalidate that of the antagonist.
In the present paper, we review the various mathematical descriptions of If that have been used in computer simulations and compare their strikingly different characteristics with our experimental data.
We identify caveats and propose a novel model for If based on our experimental data.
American Psychological Association (APA)
Verkerk, Arie O.& Wilders, Ronald. 2013. Hyperpolarization-Activated Current, If, in Mathematical Models of Rabbit Sinoatrial Node Pacemaker Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1005321
Modern Language Association (MLA)
Verkerk, Arie O.& Wilders, Ronald. Hyperpolarization-Activated Current, If, in Mathematical Models of Rabbit Sinoatrial Node Pacemaker Cells. BioMed Research International No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-1005321
American Medical Association (AMA)
Verkerk, Arie O.& Wilders, Ronald. Hyperpolarization-Activated Current, If, in Mathematical Models of Rabbit Sinoatrial Node Pacemaker Cells. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1005321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005321