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Influenza Virus Specific CD8+ T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice
Joint Authors
Parzych, E. M.
DiMenna, L. J.
Latimer, B. P.
Small, J. C.
Kannan, S.
Manson, B.
Lasaro, M. O.
Wherry, E. J.
Ertl, H. C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Influenza viruses cause severe illnesses and death, mainly in the aged population.
Protection afforded by licensed vaccines through subtype-specific neutralizing antibodies is incomplete, especially when the vaccine antigens fail to closely match those of the circulating viral strains.
Efforts are underway to generate a so-called universal influenza vaccine expressing conserved viral sequences that induce broad protection to multiple strains of influenza virus through the induction of CD8+ T cells.
Here we assess the effect of a potent antiviral CD8+ T cell response on influenza virus infection of young and aged mice.
Our results show that CD8+ T cell-inducing vaccines can provide some protection to young mice, but they exacerbate influenza virus-associated disease in aged mice, causing extensive lung pathology and death.
American Psychological Association (APA)
Parzych, E. M.& DiMenna, L. J.& Latimer, B. P.& Small, J. C.& Kannan, S.& Manson, B.…[et al.]. 2013. Influenza Virus Specific CD8+ T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1005329
Modern Language Association (MLA)
Parzych, E. M.…[et al.]. Influenza Virus Specific CD8+ T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1005329
American Medical Association (AMA)
Parzych, E. M.& DiMenna, L. J.& Latimer, B. P.& Small, J. C.& Kannan, S.& Manson, B.…[et al.]. Influenza Virus Specific CD8+ T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1005329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005329