Vitamin C Intake Reduces the Cytotoxicity Associated with Hyperglycemia in Prediabetes and Type 2 Diabetes
Joint Authors
Prá, Daniel
Franke, Silvia Isabel Rech
Müller, Luiza Louzada
Santos, Maria Carolina
Fishborn, Arcênio
Hermes, Liziane
Molz, Patrícia
Pereira, Camila Schreiner
Wichmann, Francisca Maria Assmann
Horta, Jorge André
Maluf, Sharbel Weidner
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hyperglycemia leads to the formation of free radicals and advanced glycation end-products (AGEs).
Antioxidants can reduce the level of protein glycation and DNA damage.
In this study, we compared the levels of vitamin C intake, which is among the most abundant antioxidants obtained from diet, with the levels of fasting plasma glucose (FPG), glycated hemoglobin (A1C), DNA damage, and cytotoxicity in prediabetic subjects and type 2 diabetic subjects.
Our results indicated that there was no significant correlation between FPG or A1C and DNA damage parameters (micronuclei, nucleoplasmic bridges, and nuclear buds).
FPG and A1C correlated with necrosis (r=0.294; P=0.013 and r=0.401; P=0.001, resp.).
Vitamin C intake correlated negatively with necrosis and apoptosis (r=-0.246; P=0.040, and r=-0.276; P=0.021, resp.).
The lack of a correlation between the FPG and A1C and DNA damage could be explained, at least in part, by the elimination of cells with DNA damage by either necrosis or apoptosis (cytotoxicity).
Vitamin C appeared to improve cell survival by reducing cytotoxicity.
Therefore, the present results indicate the need for clinical studies to evaluate the effect of low-dose vitamin C supplementation in type 2 diabetes.
American Psychological Association (APA)
Franke, Silvia Isabel Rech& Müller, Luiza Louzada& Santos, Maria Carolina& Fishborn, Arcênio& Hermes, Liziane& Molz, Patrícia…[et al.]. 2013. Vitamin C Intake Reduces the Cytotoxicity Associated with Hyperglycemia in Prediabetes and Type 2 Diabetes. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005348
Modern Language Association (MLA)
Franke, Silvia Isabel Rech…[et al.]. Vitamin C Intake Reduces the Cytotoxicity Associated with Hyperglycemia in Prediabetes and Type 2 Diabetes. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005348
American Medical Association (AMA)
Franke, Silvia Isabel Rech& Müller, Luiza Louzada& Santos, Maria Carolina& Fishborn, Arcênio& Hermes, Liziane& Molz, Patrícia…[et al.]. Vitamin C Intake Reduces the Cytotoxicity Associated with Hyperglycemia in Prediabetes and Type 2 Diabetes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005348