Crystal Structure of the FAD-Containing Ferredoxin-NADP+ Reductase from the Plant Pathogen Xanthomonas axonopodis pv. citri
Joint Authors
Tondo, María Laura
Hurtado-Guerrero, Ramon
Ceccarelli, Eduardo A.
Medina, Milagros
Orellano, Elena G.
Martínez-Júlvez, Marta
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We have solved the structure of ferredoxin-NADP(H) reductase, FPR, from the plant pathogen Xanthomonas axonopodis pv.
citri, responsible for citrus canker, at a resolution of 1.5 Å.
This structure reveals differences in the mobility of specific loops when compared to other FPRs, probably unrelated to the hydride transfer process, which contributes to explaining the structural and functional divergence between the subclass I FPRs.
Interactions of the C-terminus of the enzyme with the phosphoadenosine of the cofactor FAD limit its mobility, thus affecting the entrance of nicotinamide into the active site.
This structure opens the possibility of rationally designing drugs against the X.
axonopodis pv.
citri phytopathogen.
American Psychological Association (APA)
Tondo, María Laura& Hurtado-Guerrero, Ramon& Ceccarelli, Eduardo A.& Medina, Milagros& Orellano, Elena G.& Martínez-Júlvez, Marta. 2013. Crystal Structure of the FAD-Containing Ferredoxin-NADP+ Reductase from the Plant Pathogen Xanthomonas axonopodis pv. citri. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005378
Modern Language Association (MLA)
Tondo, María Laura…[et al.]. Crystal Structure of the FAD-Containing Ferredoxin-NADP+ Reductase from the Plant Pathogen Xanthomonas axonopodis pv. citri. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005378
American Medical Association (AMA)
Tondo, María Laura& Hurtado-Guerrero, Ramon& Ceccarelli, Eduardo A.& Medina, Milagros& Orellano, Elena G.& Martínez-Júlvez, Marta. Crystal Structure of the FAD-Containing Ferredoxin-NADP+ Reductase from the Plant Pathogen Xanthomonas axonopodis pv. citri. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005378