Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species
Joint Authors
Jenkins, Noah C.
Grossman, Douglas
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We have recently reported a potential alternative tumor suppressor function for p16 relating to its capacity to regulate oxidative stress and observed that oxidative dysregulation in p16-depleted cells was most profound in melanocytes, compared to keratinocytes or fibroblasts.
Moreover, in the absence of p16 depletion or exogenous oxidative insult, melanocytes exhibited significantly higher basal levels of reactive oxygen species (ROS) than these other epidermal cell types.
Given the role of oxidative stress in melanoma development, we speculated that this increased susceptibility of melanocytes to oxidative stress (and greater reliance on p16 for suppression of ROS) may explain why genetic compromise of p16 is more commonly associated with predisposition to melanoma rather than other cancers.
Here we show that the presence of melanin accounts for this differential oxidative stress in normal and p16-depleted melanocytes.
Thus the presence of melanin in the skin appears to be a double-edged sword: it protects melanocytes as well as neighboring keratinocytes in the skin through its capacity to absorb UV radiation, but its synthesis in melanocytes results in higher levels of intracellular ROS that may increase melanoma susceptibility.
American Psychological Association (APA)
Jenkins, Noah C.& Grossman, Douglas. 2013. Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species. BioMed Research International،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-1005383
Modern Language Association (MLA)
Jenkins, Noah C.& Grossman, Douglas. Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species. BioMed Research International No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-1005383
American Medical Association (AMA)
Jenkins, Noah C.& Grossman, Douglas. Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-1005383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005383