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Off-Label Use of Ondansetron in Pregnancy in Western Australia
Joint Authors
Colvin, Lyn
Gill, Andrew W.
Slack-Smith, Linda
Stanley, Fiona J.
Bower, Carol
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
Nausea and vomiting of pregnancy is the most common medical condition in pregnancy.
There is an increasing trend to prescribe ondansetron although its safety for use in pregnancy has not been established.
Methods.
Exposed pregnancies were all births in Western Australia, 2002–2005, where the mother was dispensed ondansetron under the Australian Pharmaceutical Benefits Scheme, compared with all other births during the same period.
Outcomes investigated include maternal and child characteristics, birth defects, pregnancy, and delivery characteristics.
Results.
There were 96,968 births from 2002 to 2005.
Ondansetron was dispensed to 251 pregnant women during this period.
The women dispensed ondansetron were more likely to be privately insured (OR: 5.8; 95% CI: 4.3–7.9), to be Caucasian (3.3; 1.9–5.7), not to smoke during their pregnancy (2.9; 1.8–4.7), to have a multiple birth (2.7; 1.5–5.0), and to have used fertility treatment (1.8; 1.0–3.4).
There was a small but not significantly increased risk of a major birth defect with first trimester exposure (1.2; 0.6–2.2).
Conclusions.
Our study did not detect any adverse outcomes from the use of ondansetron in pregnancy but could not conclude that ondansetron is safe to use in pregnancy.
American Psychological Association (APA)
Colvin, Lyn& Gill, Andrew W.& Slack-Smith, Linda& Stanley, Fiona J.& Bower, Carol. 2013. Off-Label Use of Ondansetron in Pregnancy in Western Australia. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005388
Modern Language Association (MLA)
Colvin, Lyn…[et al.]. Off-Label Use of Ondansetron in Pregnancy in Western Australia. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005388
American Medical Association (AMA)
Colvin, Lyn& Gill, Andrew W.& Slack-Smith, Linda& Stanley, Fiona J.& Bower, Carol. Off-Label Use of Ondansetron in Pregnancy in Western Australia. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005388