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Robust Cell Size Checkpoint from Spatiotemporal Positive Feedback Loop in Fission Yeast
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cells must maintain appropriate cell size during proliferation.
Size control may be regulated by a size checkpoint that couples cell size to cell division.
Biological experimental data suggests that the cell size is coupled to the cell cycle in two ways: the rates of protein synthesis and the cell polarity protein kinase Pom1 provide spatial information that is used to regulate mitosis inhibitor Wee1.
Here a mathematical model involving these spatiotemporal regulations was developed and used to explore the mechanisms underlying the size checkpoint in fission yeast.
Bifurcation analysis shows that when the spatiotemporal regulation is coupled to the positive feedback loops (active Cdc2 promotes its activator, Cdc25, and suppress its inhibitor, Wee1), the mitosis-promoting factor (MPF) exhibits a bistable steady-state relationship with the cell size.
The switch-like response from the positive feedback loops naturally generates the cell size checkpoint.
Further analysis indicated that the spatial regulation provided by Pom1 enhances the robustness of the size checkpoint in fission yeast.
This was consistent with experimental data.
American Psychological Association (APA)
Yan, Jie& Ni, Xin& Yang, Ling. 2013. Robust Cell Size Checkpoint from Spatiotemporal Positive Feedback Loop in Fission Yeast. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005390
Modern Language Association (MLA)
Yan, Jie…[et al.]. Robust Cell Size Checkpoint from Spatiotemporal Positive Feedback Loop in Fission Yeast. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005390
American Medical Association (AMA)
Yan, Jie& Ni, Xin& Yang, Ling. Robust Cell Size Checkpoint from Spatiotemporal Positive Feedback Loop in Fission Yeast. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005390