![](/images/graphics-bg.png)
New Guar Biopolymer Silver Nanocomposites for Wound Healing Applications
Joint Authors
Ghosh Auddy, Runa
Abdullah, Md Farooque
Das, Suvadra
Roy, Partha
Datta, Sriparna
Mukherjee, Arup
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Wound healing is an innate physiological response that helps restore cellular and anatomic continuity of a tissue.
Selective biodegradable and biocompatible polymer materials have provided useful scaffolds for wound healing and assisted cellular messaging.
In the present study, guar gum, a polymeric galactomannan, was intrinsically modified to a new cationic biopolymer guar gum alkylamine (GGAA) for wound healing applications.
Biologically synthesized silver nanoparticles (Agnp) were further impregnated in GGAA for extended evaluations in punch wound models in rodents.
SEM studies showed silver nanoparticles well dispersed in the new guar matrix with a particle size of ~18 nm.
In wound healing experiments, faster healing and improved cosmetic appearance were observed in the new nanobiomaterial treated group compared to commercially available silver alginate cream.
The total protein, DNA, and hydroxyproline contents of the wound tissues were also significantly higher in the treated group as compared with the silver alginate cream (P<0.05).
Silver nanoparticles exerted positive effects because of their antimicrobial properties.
The nanobiomaterial was observed to promote wound closure by inducing proliferation and migration of the keratinocytes at the wound site.
The derivatized guar gum matrix additionally provided a hydrated surface necessary for cell proliferation.
American Psychological Association (APA)
Ghosh Auddy, Runa& Abdullah, Md Farooque& Das, Suvadra& Roy, Partha& Datta, Sriparna& Mukherjee, Arup. 2013. New Guar Biopolymer Silver Nanocomposites for Wound Healing Applications. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005393
Modern Language Association (MLA)
Ghosh Auddy, Runa…[et al.]. New Guar Biopolymer Silver Nanocomposites for Wound Healing Applications. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005393
American Medical Association (AMA)
Ghosh Auddy, Runa& Abdullah, Md Farooque& Das, Suvadra& Roy, Partha& Datta, Sriparna& Mukherjee, Arup. New Guar Biopolymer Silver Nanocomposites for Wound Healing Applications. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005393