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Prior Lung Inflammation Impacts on Body Distribution of Gold Nanoparticles
Joint Authors
Hussain, Salik
Vanoirbeek, Jeroen A. J.
Haenen, Steven
Haufroid, Vincent
Boland, Sonja
Marano, Francelyne
Nemery, Benoit
Hoet, Peter H. M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Gold- (Au-) based nanomaterials have shown promising potential in nanomedicine.
The individual health status is an important determinant of the response to injury/exposure.
It is, therefore, critical to evaluate exposure to Au-nanomaterials with varied preexisting health status.
Objective.
The goal of this research was to determine the extent of extrapulmonary translocation from healthy and inflamed lungs after pulmonary exposure to AuNPs.
Male BALB/c mice received a single dose of 0.8 mg·kg−1 AuNPs (40 nm) by oropharyngeal aspiration 24 hours after priming with LPS (0.4 mg·kg−1) through the same route.
Metal contents were analyzed in different organs by inductively coupled plasma-mass spectrometry (ICP-MS).
Results.
Oropharyngeal aspiration resulted in high metal concentrations in lungs (P<0.001); however, these were much lower after pretreatment with LPS (P<0.05).
Significantly higher concentrations of Au were detected in heart and thymus of healthy animals, whereas higher concentrations of Au NPs were observed in spleen in LPS-primed animals.
Conclusions.
The distribution of AuNPs from lungs to secondary target organs depends upon the health status, indicating that targeting of distinct secondary organs in nanomedicine needs to be considered carefully under health and inflammatory conditions.
American Psychological Association (APA)
Hussain, Salik& Vanoirbeek, Jeroen A. J.& Haenen, Steven& Haufroid, Vincent& Boland, Sonja& Marano, Francelyne…[et al.]. 2013. Prior Lung Inflammation Impacts on Body Distribution of Gold Nanoparticles. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005422
Modern Language Association (MLA)
Hussain, Salik…[et al.]. Prior Lung Inflammation Impacts on Body Distribution of Gold Nanoparticles. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005422
American Medical Association (AMA)
Hussain, Salik& Vanoirbeek, Jeroen A. J.& Haenen, Steven& Haufroid, Vincent& Boland, Sonja& Marano, Francelyne…[et al.]. Prior Lung Inflammation Impacts on Body Distribution of Gold Nanoparticles. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005422