Role of Sex Steroid Hormones in Bacterial-Host Interactions
Joint Authors
Camacho-Arroyo, Ignacio
García-Gómez, Elizabeth
González-Pedrajo, Bertha
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sex steroid hormones play important physiological roles in reproductive and nonreproductive tissues, including immune cells.
These hormones exert their functions by binding to either specific intracellular receptors that act as ligand-dependent transcription factors or membrane receptors that stimulate several signal transduction pathways.
The elevated susceptibility of males to bacterial infections can be related to the usually lower immune responses presented in males as compared to females.
This dimorphic sex difference is mainly due to the differential modulation of the immune system by sex steroid hormones through the control of proinflammatory and anti-inflammatory cytokines expression, as well as Toll-like receptors (TLRs) expression and antibody production.
Besides, sex hormones can also affect the metabolism, growth, or virulence of pathogenic bacteria.
In turn, pathogenic, microbiota, and environmental bacteria are able to metabolize and degrade steroid hormones and their related compounds.
All these data suggest that sex steroid hormones play a key role in the modulation of bacterial-host interactions.
American Psychological Association (APA)
García-Gómez, Elizabeth& González-Pedrajo, Bertha& Camacho-Arroyo, Ignacio. 2012. Role of Sex Steroid Hormones in Bacterial-Host Interactions. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005442
Modern Language Association (MLA)
García-Gómez, Elizabeth…[et al.]. Role of Sex Steroid Hormones in Bacterial-Host Interactions. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005442
American Medical Association (AMA)
García-Gómez, Elizabeth& González-Pedrajo, Bertha& Camacho-Arroyo, Ignacio. Role of Sex Steroid Hormones in Bacterial-Host Interactions. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005442