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Potential of RAS Inhibition to Improve Metabolic Bone Disorders
Joint Authors
Gebru, Yoseph
Diao, Teng-Yue
Pan, Hai
Mukwaya, Emmanuel
Zhang, Yan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Metabolic bone disorder is usually caused by abnormalities of minerals and hormones metabolism.
Recently, it has been proved by several studies that the renin-angiotensin system (RAS) in local bone tissue is directly involved in bone metabolism.
Activation of skeletal RAS plays an important role in bone metabolic disorders.
Based on in vitro, in vivo, and clinical studies, this review explains the roles of RAS in bone metabolism and also covers the potential approaches and beneficial effects of RAS inhibition on bone health.
Differential strategies for inhibiting RAS can be employed to maintain bone health, which are attributed primarily to the reduced level of angiotensin II (AngII) and suppressed stimulation of the AngII signaling pathway.
The use of renin inhibitors, angiotensin-converting enzyme inhibitors, and AngII receptor blockers either individually or in combination with each other could have promising results in fighting bone metabolic disorders associated with other cardiovascular diseases as well as independent bone injuries.
American Psychological Association (APA)
Gebru, Yoseph& Diao, Teng-Yue& Pan, Hai& Mukwaya, Emmanuel& Zhang, Yan. 2013. Potential of RAS Inhibition to Improve Metabolic Bone Disorders. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005460
Modern Language Association (MLA)
Gebru, Yoseph…[et al.]. Potential of RAS Inhibition to Improve Metabolic Bone Disorders. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005460
American Medical Association (AMA)
Gebru, Yoseph& Diao, Teng-Yue& Pan, Hai& Mukwaya, Emmanuel& Zhang, Yan. Potential of RAS Inhibition to Improve Metabolic Bone Disorders. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005460